Olivia is working on a project joint with Professor Stephen Faulkner studying the crystal structures of novel thiosemicarbazides and their metal complexes. When not in the lab she can be found playing netball or ice-skating.
Nia’s Part II project is focused on the preparation and systematic study of thiosemicarbazone complexes by single crystal X-ray diffraction. When not in the lab she may be found listening to music at live venues, or perhaps sampling some of Oxford’s fine real ales.
Inorg. Chim. Acta (2010), 363(6), 1140-1149. [ doi:10.1016/j.ica.2009.10.020 ]
Four 2-acetylpyridine 4N-alkyl thiosemicarbazones, and their Ga(III) and In(III) complexes have been prepared and characterised by fluorescence, UV–Vis, IR, 1H and 13C NMR spectroscopy, mass spectrometry and X-ray crystallographic analysis. Comparison of the crystal structures gave an insight into the nature of the complexes formed, demonstrating a preference for [ML2]+ type complexes with gallium and [MLX3] species with indium. Stability studies on two candidates indicated that complex [InL3Cl2MeOH] was stable to chemical degradation for prolonged periods in human serum, giving this complex potential for further biological evaluation.
- Oxford University Research Archive [direct pdf]