Oct 302009

Inorg. Chim. Acta  (2010), 363(6), 1140-1149.    [ doi:10.1016/j.ica.2009.10.020 ]

Four 2-acetylpyridine 4N-alkyl thiosemicarbazones, and their Ga(III) and In(III) complexes have been prepared and characterised by fluorescence, UV–Vis, IR, 1H and 13C NMR spectroscopy, mass spectrometry and X-ray crystallographic analysis. Comparison of the crystal structures gave an insight into the nature of the complexes formed, demonstrating a preference for [ML2]+ type complexes with gallium and [MLX3] species with indium. Stability studies on two candidates indicated that complex [InL3Cl2MeOH] was stable to chemical degradation for prolonged periods in human serum, giving this complex potential for further biological evaluation.

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Thiosemicarbazone overlay

Overlay of two thiosemicarbazone ligands showing two different conformations.